Opportunity Information: Apply for RFA MH 22 292
The BRAIN Initiative Cell Atlas Network (BICAN) Specialized Collaboratory FOA (RFA-MH-22-292) is a National Institutes of Health (NIH) grant opportunity that funds R01 projects focused on building detailed, reference-quality brain cell atlases across three key species: human, non-human primate, and mouse. The central purpose is to expand the BICAN ecosystem by supporting a set of "Specialized Collaboratories" that bring unique strengths, methods, and scientific aims, working in close coordination with other BICAN-funded efforts. These collaboratories are meant to complement (not duplicate) the larger Comprehensive Centers by providing distinct capabilities, specialized technical pipelines, or focused anatomical or methodological coverage that helps the overall network reach a more complete and granular atlas of brain cell types and states.
At the heart of the FOA is the expectation that awardees will adopt scalable technology platforms and apply streamlined sampling strategies along with an organized "assay cascade." In practical terms, this means projects should be built for throughput, consistency, and comparability, using methods that can be applied broadly rather than boutique approaches that only work in narrow settings. The sampling plan is expected to be efficient and systematic so that collected tissue and resulting datasets contribute cleanly to a coordinated atlas effort. The assay cascade concept implies that multiple measurement types may be layered in a planned sequence (for example, starting with broad profiling and then adding deeper or spatially resolved assays where needed) so that the final atlas products are both comprehensive and highly detailed at the cellular level, capturing molecular signatures and anatomical context.
The overarching goal of BICAN, which this FOA directly supports, is to produce widely usable reference brain cell atlases that the broader research community can rely on as foundational infrastructure. These atlases are intended to provide a shared molecular and anatomical framework for studying how the brain works and how brain disorders arise. By standardizing and expanding cell-type and cell-state definitions across species, the program aims to make it easier to compare findings across labs, map disease-associated signals to specific cell populations, and connect experimental model systems (especially mouse and non-human primate) to human brain biology. The emphasis on coordination and collaboration indicates that data, methods, and outputs are expected to integrate with other BICAN components rather than remain siloed within individual projects.
This opportunity uses the NIH R01 grant mechanism and is explicitly "Clinical Trial Not Allowed," meaning applications should not propose clinical trials as part of the funded work. The funding instrument is a discretionary grant, and the activity categories associated with the listing include education and health-related domains. The FOA is cataloged under multiple CFDA numbers (93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867), reflecting NIH institute participation and the cross-cutting nature of the BRAIN Initiative.
Eligibility is broad and includes many types of U.S.-based institutions and organizations, such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and multiple levels of government applicants (state, county, city/township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. Tribal eligibility includes federally recognized Native American tribal governments and other Native American tribal organizations. The FOA also highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), along with faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities, indicating an intent to include a wide range of contributors with relevant expertise and resources.
Key administrative details in the provided source include the opportunity title "BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (R01 Clinical Trial Not Allowed)," the funding opportunity number RFA-MH-22-292, the agency being NIH, and an original closing date of February 1, 2024. The award ceiling and expected number of awards are not specified in the source text you provided, but the program description makes clear that NIH intends to support a group of collaboratories rather than a single award, reinforcing the networked, coordinated nature of BICAN.
Overall, the FOA is best understood as a call for teams that can contribute high-value, scalable, and integrative atlas-building capacity to a national consortium. Successful projects are expected to generate highly granular, harmonizable brain cell atlas data in human, non-human primate, and mouse, and to do so in a way that strengthens the shared reference resources that many other neuroscience and neuropsychiatric research efforts will build upon.Apply for RFA MH 22 292
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "BRAIN Initiative Cell Atlas Network (BICAN): Specialized Collaboratory on Human, Non-human Primate, and Mouse Brain Cell Atlases (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.213, 93.242, 93.273, 93.279, 93.286, 93.853, 93.865, 93.866, 93.867.
- This funding opportunity was created on 2022-10-03.
- Applicants must submit their applications by 2024-02-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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