Opportunity Information: Apply for PAR 25 213
This NIH grant opportunity (PAR-25-213) supports R01 research projects focused on implementation research for managing multi-morbidity in the context of noncommunicable diseases (NCDs). The core idea is not simply to test whether an intervention works in ideal conditions, but to study how evidence-based approaches to NCD prevention and care can be adopted, delivered, improved, and sustained in real-world settings where people commonly live with more than one chronic condition at the same time. The opportunity is issued by participating NIH Institutes and Centers in partnership with the Global Alliance for Chronic Diseases (GACD), signaling a strong emphasis on practical, scalable solutions that can move effective NCD strategies into routine care and community systems.
The geographic and population focus is clearly defined. Projects must address NCD-related multi-morbidity management in World Bank-defined low- and middle-income countries (LMICs) and/or in American Indian and Alaska Native (AI/AN) Tribal Nation populations within the United States. This reflects a priority to improve outcomes in settings that often face disproportionate NCD burden, gaps in access to coordinated chronic care, workforce and infrastructure limitations, and structural barriers that can make long-term disease management difficult. By explicitly including US Tribal Nation populations alongside LMIC settings, the program underscores shared implementation challenges such as delivering culturally grounded care, strengthening health systems, and ensuring interventions remain feasible and sustainable over time.
The research mechanism is an R01, and clinical trials are optional, meaning applicants may propose studies with or without a clinical trial component as long as the work is grounded in implementation research. In practice, that usually means projects could test strategies like care integration models, task-shifting and team-based care, patient navigation, digital health supports, medication access and adherence systems, quality improvement approaches, community-clinical linkages, or policy and financing levers, with outcomes focused on implementation success (for example, uptake, fidelity, reach, acceptability, feasibility, cost, and sustainability) alongside relevant health outcomes. The emphasis on multi-morbidity also implies interest in approaches that reduce fragmentation and improve coordination across conditions rather than addressing a single disease in isolation.
Eligibility is broad and designed to encourage participation from a wide range of institutions and organizations. Eligible applicants include federal, state, county, city, township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other entities. The announcement also highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, non-domestic (non-US) entities/foreign organizations, US territories or possessions, and Indian/Native American Tribal Governments that are not federally recognized. Overall, NIH is signaling that strong implementation partnerships can come from academic centers, health systems, Tribal entities, community organizations, and cross-sector coalitions, including international partners in LMIC contexts.
From a funding and timing standpoint, the opportunity is categorized as a discretionary grant within NIH program areas spanning health and related social services (the listing includes multiple CFDA/assistance listing numbers, reflecting participation across NIH components). The stated award ceiling is $500,000 (as provided in the source data). The original application closing date is January 7, 2026. The opportunity record lists expected awards but does not provide a number in the provided source, so applicants should plan with the understanding that awards will depend on NIH priorities, available funds, and application quality.
In practical terms, a competitive application will typically show a strong rationale for the implementation problem being addressed, a clear evidence base for the intervention(s) being implemented, and a rigorous plan to study implementation in real-world conditions. Because the target contexts include LMICs and Tribal Nation populations, reviewers generally look for genuine partnerships, cultural and contextual fit, and plans that strengthen local capacity while producing lessons that can be adapted or scaled. The overarching goal is to generate actionable evidence on how to improve delivery and long-term management of NCD care for people living with multiple chronic conditions in settings where the need is high and the path from evidence to routine practice is often the hardest.Apply for PAR 25 213
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Implementation Research for Multi-morbidity Management in the Context of Non-communicable Diseases in Low- and Middle-Income Countries and US Tribal Populations (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.242, 93.313, 93.393, 93.399, 93.837, 93.838, 93.839, 93.840, 93.853, 93.865, 93.866, 93.867, 93.989.
- This funding opportunity was created on 2024-10-25.
- Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): NIH PAR-25-213 (R01) Implementation Research for NCD Multi-morbidity
What is PAR-25-213?
PAR-25-213 is an NIH grant opportunity supporting R01 research projects focused on implementation research for managing multi-morbidity in the context of noncommunicable diseases (NCDs). The emphasis is on how evidence-based approaches to NCD prevention and care can be adopted, delivered, improved, and sustained in real-world settings where people often live with more than one chronic condition.
What is the main goal of this funding opportunity?
The main goal is to generate actionable evidence on how to improve delivery and long-term management of NCD care for people living with multiple chronic conditions, especially in settings where the burden is high and the path from evidence to routine practice is challenging.
What type of research does the opportunity prioritize?
This opportunity prioritizes implementation research rather than research designed only to test whether an intervention works under ideal conditions. Projects should study how evidence-based interventions and strategies can be effectively integrated into routine care and community systems.
What does "implementation research" mean in this context?
In this context, implementation research focuses on practical questions of real-world delivery, such as how an evidence-based approach is adopted, how well it is delivered (including fidelity), who it reaches, whether it is acceptable and feasible in the setting, what it costs, and whether it can be sustained over time.
What health topic areas are in scope?
The scope is NCD-related multi-morbidity management. The opportunity specifically emphasizes approaches that reduce fragmentation and improve coordination across conditions rather than addressing a single disease in isolation.
What does "multi-morbidity" refer to for this announcement?
Multi-morbidity refers to people living with more than one chronic condition at the same time. The opportunity is focused on improving the management of these overlapping needs within NCD prevention and care systems.
Where must the research take place (geographic focus)?
Projects must address NCD-related multi-morbidity management in either World Bank-defined low- and middle-income countries (LMICs) and/or American Indian and Alaska Native (AI/AN) Tribal Nation populations within the United States.
Can a project include both LMIC and AI/AN Tribal Nation settings?
Yes. The stated focus includes LMICs and/or AI/AN Tribal Nation populations, which allows projects to be designed for one or both of these priority contexts as long as they address NCD-related multi-morbidity management.
Why does the opportunity focus on LMICs and AI/AN Tribal Nation populations?
The opportunity reflects a priority to improve outcomes in settings that often face disproportionate NCD burden and challenges such as gaps in access to coordinated chronic care, workforce and infrastructure limitations, and structural barriers that make long-term disease management difficult. It also underscores shared implementation challenges such as culturally grounded care, health system strengthening, and long-term feasibility and sustainability.
What is the funding mechanism?
The funding mechanism is an NIH R01 research project grant.
Are clinical trials allowed under this opportunity?
Yes. Clinical trials are optional. Applicants may propose studies with or without a clinical trial component as long as the project is grounded in implementation research.
What kinds of strategies or approaches might be appropriate to study?
Examples of strategies mentioned include care integration models, task-shifting and team-based care, patient navigation, digital health supports, medication access and adherence systems, quality improvement approaches, community-clinical linkages, and policy and financing levers. Projects are expected to examine how these approaches can be implemented effectively in real-world settings.
What outcomes are expected for implementation research projects?
Projects are expected to focus on implementation outcomes such as uptake, fidelity, reach, acceptability, feasibility, cost, and sustainability, alongside relevant health outcomes.
Does the opportunity require an evidence base for the intervention being implemented?
Yes. A competitive application is expected to present a clear evidence base for the intervention(s) being implemented and a strong rationale for the implementation problem being addressed.
What kinds of partnerships are encouraged or expected?
Because the focus includes LMICs and Tribal Nation populations, the opportunity emphasizes genuine partnerships, cultural and contextual fit, and plans that strengthen local capacity while producing lessons that can be adapted or scaled.
Who is issuing this funding opportunity?
The opportunity is issued by participating NIH Institutes and Centers in partnership with the Global Alliance for Chronic Diseases (GACD), highlighting an emphasis on practical and scalable solutions that can move effective NCD strategies into routine systems.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include various government entities (federal, state, county, city, township, special district), independent school districts, public housing authorities/Indian housing authorities, public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and other entities.
Are community-based and faith-based organizations eligible?
Yes. The opportunity explicitly includes faith-based and community-based organizations among eligible groups.
Are Tribal entities eligible to apply?
Yes. Eligibility includes Indian/Native American Tribal Governments that are not federally recognized, as well as Tribally Controlled Colleges and Universities (TCCUs). The opportunity also targets AI/AN Tribal Nation populations as a key focus area.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility list includes non-domestic (non-U.S.) entities/foreign organizations, consistent with the focus on LMIC settings.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicant types.
Does the opportunity mention specific minority-serving institutions as eligible?
Yes. It highlights eligibility for institutions such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other regional organizations.
What is the maximum award amount (award ceiling)?
The stated award ceiling is $500,000 (as provided in the source information).
When is the application due?
The original application closing date is January 7, 2026.
How many awards will be made?
The opportunity record lists expected awards, but the number of awards is not provided in the source information. Applicants should plan with the understanding that awards depend on NIH priorities, available funds, and application quality.
What makes an application competitive based on the provided information?
Based on the provided information, a competitive application typically includes: a strong rationale for the implementation problem, a clear evidence base for the intervention(s), a rigorous plan to study implementation in real-world conditions, genuine partnerships in LMIC and/or Tribal Nation contexts, cultural and contextual fit, capacity-strengthening elements, and a focus on producing lessons that can be adapted or scaled.
Is this opportunity focused on scaling and sustainability?
Yes. The opportunity signals a strong emphasis on practical, scalable solutions and specifically highlights sustainability as a key implementation outcome of interest.
Is the program focused on routine care and community systems?
Yes. The opportunity emphasizes moving effective NCD strategies into routine care and community systems rather than keeping them limited to controlled or ideal research environments.
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| BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UG3/UH3 Clinical Trial Optional) Apply for RFA NS 25 021 Funding Number: RFA NS 25 021 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System (UH3 Clinical Trial Optional) Apply for RFA NS 25 022 Funding Number: RFA NS 25 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional) Apply for PAR 25 117 Funding Number: PAR 25 117 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed) Apply for RFA MH 26 170 Funding Number: RFA MH 26 170 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) Apply for PAR 25 109 Funding Number: PAR 25 109 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R21 Clinical Trial Optional) Apply for PAR 25 111 Funding Number: PAR 25 111 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Translational Research in Maternal and Pediatric Pharmacology and Therapeutics (R01 Clinical Trial Optional) Apply for PAR 25 110 Funding Number: PAR 25 110 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required) Apply for PAR 25 148 Funding Number: PAR 25 148 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Promoting Equity Through BRAIN Technology Partnerships (R34 - Clinical Trials Not Allowed) Apply for RFA NS 25 016 Funding Number: RFA NS 25 016 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| New Approaches for Measuring Brain Changes Across Longer Timespans (R21 Clinical Trial Optional) Apply for PAR 25 272 Funding Number: PAR 25 272 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| New Approaches for Measuring Brain Changes Across Longer Timespans (R01 Clinical Trial Optional) Apply for PAR 25 279 Funding Number: PAR 25 279 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional) Apply for PAR 25 242 Funding Number: PAR 25 242 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed) Apply for PAR 25 154 Funding Number: PAR 25 154 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $100,000 |
| HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional) Apply for RFA DA 25 077 Funding Number: RFA DA 25 077 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $750,000 |
| HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R61/R33 Clinical Trial Optional) Apply for RFA DA 25 078 Funding Number: RFA DA 25 078 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Project Grant (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 25 307 Funding Number: PA 25 307 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition: Data Analysis and Sharing Center (DASC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Apply for RFA HL 26 010 Funding Number: RFA HL 26 010 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000,000 |
| Limited Competition: Clinical Research Sites (CRS) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trial Not Allowed) Apply for RFA HL 26 009 Funding Number: RFA HL 26 009 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,400,000 |
| Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Apply for RFA HL 26 011 Funding Number: RFA HL 26 011 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $2,000 |
| Single Source: National Longitudinal Study of Adolescent to Adult (Add) Health Wave VII (U01 Clinical Trial Not Allowed) Apply for RFA AG 26 001 Funding Number: RFA AG 26 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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